Dextromethorphan

CHEMBL52440 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

271.4 g/mol

LogP

3.4

Phase

4

A synthetic opioid analogue without analgesic properties that suppresses cough by acting on sigma receptors and NMDA receptors in the brain stem, widely used as an over-the-counter antitussive. At high doses it can cause dissociative hallucinations and is subject to misuse.

Peso Molecular

271,4000 g/mol

LogP

3,40

TPSA

12,50 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Alzheimer's Disease Parkinson's Disease Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Melanoma Psoriasis Multiple Sclerosis Stroke Obesity Lymphoma Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain Malaria Tuberculosis Prostate Cancer Leukemia

Mecanismo de Ação

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …

Estrutura 2D

SVG PNG

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SMILES

COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3

InChI

InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1

Molecular Formula

C18H25NO

HBD / HBA

- / 2

Ligações Rotacionáveis

1

Átomos Pesados

20

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

A synthetic opioid analogue without analgesic properties that suppresses cough by acting on sigma receptors and NMDA receptors in the brain stem, widely used as an over-the-counter antitussive. At high doses it can cause dissociative hallucinations and is subject to misuse.

Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.

Yes, Dextromethorphan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL52440. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5360696. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

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Estrutura

Dados Rápidos

Fórmula: C18H25NO
Sinônimos: 1671

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.