Dextromethorphan
A synthetic opioid analogue without analgesic properties that suppresses cough by acting on sigma receptors and NMDA receptors in the brain stem, widely used as an over-the-counter antitussive. At high doses it can cause dissociative hallucinations and is subject to misuse.
Khối lượng phân tử
271,4000 g/mol
LogP
3,40
TPSA
12,50 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
InChI
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
Molecular Formula
C18H25NO
HBD / HBA
- / 2
Liên kết có thể quay
1
Nguyên tử nặng
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A synthetic opioid analogue without analgesic properties that suppresses cough by acting on sigma receptors and NMDA receptors in the brain stem, widely used as an over-the-counter antitussive. At high doses it can cause dissociative hallucinations and is subject to misuse.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Dextromethorphan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL52440. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5360696. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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