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Hydroxyzine Pamoate

CHEMBL1200467 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
763.3 g/mol
LogP
—
Phase
4

This pamoate salt form of hydroxyzine is used in capsule form for anxiety and tension relief, as well as allergic conditions. The pamoate salt allows for a slightly different absorption profile compared to the hydrochloride salt. Like other hydroxyzine formulations, it carries anticholinergic side effects including dry mouth and drowsiness.

Peso Molecular

763,3000 g/mol

TPSA

151,00 Ų

Áreas Terapêuticas

Ovarian Cancer Pain Management Non-Small Cell Lung Cancer Asthma Migraine Schizophrenia Generalized Anxiety Disorder Oncology Multiple Sclerosis Type 2 Diabetes Major Depressive Disorder Breast Cancer Atopic Dermatitis Chronic Pain Colorectal Cancer

Mecanismo de Ação

Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C23H16O6.C21H27ClN2O2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-10,24-25H,11H2,(H,26,27)(H,28,29);1-9,21,25H,10-17H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C44H43ClN2O8

                    

                    
                    

                        
HBD / HBA

                        
5 / 10

                    

                    
                    

                        
Ligações Rotacionáveis

                        
12

                    

                    
                    
                    

                        
Átomos Pesados

                        
55

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
This pamoate salt form of hydroxyzine is used in capsule form for anxiety and tension relief, as well as allergic conditions. The pamoate salt allows for a slightly different absorption profile compared to the hydrochloride salt. Like other hydroxyzine formulations, it carries anticholinergic side effects including dry mouth and drowsiness.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Hydroxyzine Pamoate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200467.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 25096.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.