Isavuconazonium Sulfate
This is the water-soluble prodrug sulfate salt form of isavuconazole, a triazole antifungal, designed for intravenous administration. After injection, it is rapidly hydrolyzed by plasma enzymes to release the active isavuconazole. This prodrug strategy overcomes the poor water solubility of isavuconazole itself.
Peso Molecular
814,8000 g/mol
TPSA
273,00 Ų
Áreas Terapêuticas
Mecanismo de Ação
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CNCC(=O)OCc1cccnc1N(C)C(=O)OC(C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1.O=S(=O)([O-])O
InChI
InChI=1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1
Molecular Formula
C35H36F2N8O9S2
HBD / HBA
3 / 17
Ligações Rotacionáveis
15
Átomos Pesados
56
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
This is the water-soluble prodrug sulfate salt form of isavuconazole, a triazole antifungal, designed for intravenous administration. After injection, it is rapidly hydrolyzed by plasma enzymes to release the active isavuconazole. This prodrug strategy overcomes the poor water solubility of isavuconazole itself.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Isavuconazonium Sulfate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3137333. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 72196309. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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