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Levodopa

CHEMBL1009 Phase 4 Aprovado Small molecule
Half-Life
1.5 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
197.2 g/mol
LogP
-2.7
Phase
4

A dopamine precursor used as the primary treatment for Parkinson's disease, where it is converted to dopamine in the brain to replace the lost chemical messenger. It is typically combined with carbidopa to enhance its effectiveness and reduce side effects.

Peso Molecular

197,1880 g/mol

LogP

-2,70

TPSA

104,00 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Age-Related Macular Degeneration Pain Management Asthma Alzheimer's Disease Parkinson's Disease Schizophrenia Generalized Anxiety Disorder Stroke Type 2 Diabetes Major Depressive Disorder Chronic Pain

Classes de Medicamentos

N — N - Nervous System

Mecanismo de Ação

Metabolic precursor of dopamine that crosses the BBB.

Pharmacokinetics (PK)

Half-Life 1.5 hours

Pharmacodynamics (PD)

Mecanismo

Metabolic precursor of dopamine that crosses the BBB.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H11NO4

                    

                    
                    

                        
HBD / HBA

                        
4 / 5

                    

                    
                    

                        
Ligações Rotacionáveis

                        
3

                    

                    
                    
                    

                        
Átomos Pesados

                        
14

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            DRD2 (Dopamine D2 Receptor)
                            Agonist
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            ABCB1 (P-glycoprotein)
                            Substrate
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Levodopa + Quetiapine
                            
                        

                        
                        
Quetiapine, a D2 receptor antagonist, pharmacodynamically opposes levodopa's dopaminergic effect, worsening Parkinson's disease motor symptoms.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Levodopa + Aripiprazole
                            
                        

                        
                        
Aripiprazole acts as a partial D2 agonist/antagonist and can oppose levodopa's dopaminergic therapy, worsening Parkinson's disease symptoms.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Levodopa + Carbamazepine
                            
                        

                        
                        
Carbamazepine may reduce levodopa efficacy through enzyme induction and pharmacodynamic antagonism, potentially worsening Parkinson's disease control.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
A dopamine precursor used as the primary treatment for Parkinson's disease, where it is converted to dopamine in the brain to replace the lost chemical messenger. It is typically combined with carbidopa to enhance its effectiveness and reduce side effects.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Metabolic precursor of dopamine that crosses the BBB.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Levodopa: Half-life: 1.5 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Levodopa is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            
            

                
                
                    ADME Journey →
                
                
                
            

            

            
            
            

                
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{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1009.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6047.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.