Levodopa
A dopamine precursor used as the primary treatment for Parkinson's disease, where it is converted to dopamine in the brain to replace the lost chemical messenger. It is typically combined with carbidopa to enhance its effectiveness and reduce side effects.
Moleküler Ağırlık
197,1880 g/mol
LogP
-2,70
TPSA
104,00 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
İlaç Sınıfları
Etki Mekanizması
Metabolic precursor of dopamine that crosses the BBB.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Metabolic precursor of dopamine that crosses the BBB.
2D Yapı
Cite this structure
Embed this structure
SMILES
N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O
InChI
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
Molecular Formula
C9H11NO4
HBD / HBA
4 / 5
Döndürülebilir Bağlar
3
Ağır Atomlar
14
Quetiapine, a D2 receptor antagonist, pharmacodynamically opposes levodopa's dopaminergic effect, worsening Parkinson's disease motor symptoms.
Aripiprazole acts as a partial D2 agonist/antagonist and can oppose levodopa's dopaminergic therapy, worsening Parkinson's disease symptoms.
Carbamazepine may reduce levodopa efficacy through enzyme induction and pharmacodynamic antagonism, potentially worsening Parkinson's disease control.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
A dopamine precursor used as the primary treatment for Parkinson's disease, where it is converted to dopamine in the brain to replace the lost chemical messenger. It is typically combined with carbidopa to enhance its effectiveness and reduce side effects.
Metabolic precursor of dopamine that crosses the BBB.
Key pharmacokinetic parameters for Levodopa: Half-life: 1.5 hours.
Yes, Levodopa is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
Same Target
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1009. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6047. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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