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Ondansetron

CHEMBL46 Phase 4 Aprovado Small molecule
Half-Life
3-5 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
293.4 g/mol
LogP
2.3
Phase
4

A selective 5-HT3 receptor antagonist, ondansetron blocks the serotonin signaling that triggers nausea and vomiting. It is used to prevent these symptoms after chemotherapy, radiation, and surgery. With the molecular formula C18H19N3O, it was among the first agents of its class and transformed the tolerability of cancer treatment by controlling emesis that older antiemetics could not.

A serotonin receptor antagonist preventing chemotherapy-induced and post-operative nausea and vomiting.

Peso Molecular

293,3660 g/mol

LogP

2,30

TPSA

39,80 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Oncology Gastroenterology

Classes de Medicamentos

A — A - Alimentary Tract and Metabolism

Mecanismo de Ação

Selective 5-HT3 receptor antagonist.

Pharmacokinetics (PK)

Half-Life 3-5 hours

Pharmacodynamics (PD)

Mecanismo

Selective 5-HT3 receptor antagonist.

Estrutura 2D

SVG PNG

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SMILES

                    
Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H19N3O

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Ligações Rotacionáveis

                        
2

                    

                    
                    
                    

                        
Átomos Pesados

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Ondansetron + Escitalopram
                            
                        

                        
                        
Escitalopram and ondansetron together carry dual risks: serotonin syndrome and additive QT interval prolongation, making this combination particularly dangerous.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Ondansetron + Azithromycin
                            
                        

                        
                        
Azithromycin and ondansetron both prolong the cardiac QT interval; their combination substantially increases the risk of torsades de pointes.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Ondansetron + Fluconazole
                            
                        

                        
                        
Fluconazole inhibits the metabolism of ondansetron and both drugs prolong the QT interval, creating a compounded arrhythmia risk.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Ondansetron + Ciprofloxacin
                            
                        

                        
                        
Ciprofloxacin and ondansetron both prolong the QT interval; combined use raises the risk of torsades de pointes and sudden cardiac death.

                        
                    
                    
                    
                        

                            

  
  Major


                            
                                Ondansetron + Hydroxychloroquine
                            
                        

                        
                        
Hydroxychloroquine and ondansetron both prolong cardiac repolarization via hERG blockade; concurrent use substantially elevates arrhythmia risk.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
A serotonin receptor antagonist preventing chemotherapy-induced and post-operative nausea and vomiting.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Selective 5-HT3 receptor antagonist.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Ondansetron: Half-life: 3-5 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Ondansetron is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Metformin
                            Small molecule
                        
                        
                        
                            Omeprazole
                            Small molecule
                        
                        
                        
                            Pantoprazole
                            Small molecule
                        
                        
                        
                            Lansoprazole
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL46.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4595.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.