Phenformin

CHEMBL170988 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

205.3 g/mol

LogP

-0.8

Phase

4

Phenformin is a biguanide-class antidiabetic agent that lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK). Although withdrawn from most markets due to a high risk of lactic acidosis, it has garnered renewed research interest as a potential antineoplastic agent, particularly in melanoma, through its effects on cellular metabolism and mTOR pathway inhibition.

Peso Molecular

205,2600 g/mol

LogP

-0,80

TPSA

103,00 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Melanoma Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

N=C(N)NC(=N)NCCc1ccccc1

InChI

InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)

Molecular Formula

C10H15N5

HBD / HBA

3 / 1

Ligações Rotacionáveis

4

Átomos Pesados

15

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Phenformin is a biguanide-class antidiabetic agent that lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK). Although withdrawn from most markets due to a high risk of lactic acidosis, it has garnered renewed research interest as a potential antineoplastic agent, particularly in melanoma, through its effects on cellular metabolism and mTOR pathway inhibition.

Yes, Phenformin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL170988. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 8249. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estrutura

Dados Rápidos

Fórmula: C10H15N5

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.