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Phenformin

CHEMBL170988 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
205.3 g/mol
LogP
-0.8
Phase
4

Phenformin is a biguanide-class antidiabetic agent that lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK). Although withdrawn from most markets due to a high risk of lactic acidosis, it has garnered renewed research interest as a potential antineoplastic agent, particularly in melanoma, through its effects on cellular metabolism and mTOR pathway inhibition.

Khối lượng phân tử

205,2600 g/mol

LogP

-0,80

TPSA

103,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Melanoma Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N=C(N)NC(=N)NCCc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H15N5

                    

                    
                    

                        
HBD / HBA

                        
3 / 1

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Phenformin is a biguanide-class antidiabetic agent that lowers blood glucose primarily by inhibiting hepatic gluconeogenesis and improving peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK). Although withdrawn from most markets due to a high risk of lactic acidosis, it has garnered renewed research interest as a potential antineoplastic agent, particularly in melanoma, through its effects on cellular metabolism and mTOR pathway inhibition.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Phenformin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL170988.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 8249.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.