Thiosulfuric Acid
Thiosulfuric acid and its sodium salt (sodium thiosulfate) function as sulfur donors and reducing agents that react with cyanide to form non-toxic thiocyanate in the liver via the enzyme rhodanese, providing life-saving antidotal therapy for cyanide poisoning. Sodium thiosulfate is also used to reduce the nephrotoxicity of cisplatin in hyperthermic intraperitoneal chemotherapy, reduce calciphylaxis lesions, and as a topical antifungal. Its role in cancer care stems from its ability to neutralize cisplatin-induced nephrotoxicity without compromising antitumor efficacy when administered systemically after intraperitoneal cisplatin.
Peso Molecular
114,1500 g/mol
LogP
0,30
TPSA
98,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
O=S(O)(O)=S
InChI
InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)
Molecular Formula
H2O3S2
HBD / HBA
2 / 4
Ligações Rotacionáveis
0
Átomos Pesados
5
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Thiosulfuric acid and its sodium salt (sodium thiosulfate) function as sulfur donors and reducing agents that react with cyanide to form non-toxic thiocyanate in the liver via the enzyme rhodanese, providing life-saving antidotal therapy for cyanide poisoning. Sodium thiosulfate is also used to reduce the nephrotoxicity of cisplatin in hyperthermic intraperitoneal chemotherapy, reduce calciphylaxis lesions, and as a topical antifungal. Its role in cancer care stems from its ability to neutralize cisplatin-induced nephrotoxicity without compromising antitumor efficacy when administered systemically …
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Thiosulfuric Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1208642. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 24478. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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