Verapamil

CHEMBL6966 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

454.6 g/mol

LogP

3.8

Phase

4

This calcium channel blocker is used to treat high blood pressure, certain heart rhythm disorders (including atrial fibrillation and supraventricular tachycardia), and angina (chest pain), and is also used to prevent migraine headaches and cluster headaches. It works by slowing the movement of calcium into heart and blood vessel muscle cells, causing the heart to beat more slowly and blood vessels to relax. It interacts with many medications, and grapefruit juice can increase its blood levels significantly.

Peso Molecular

454,6000 g/mol

LogP

3,80

TPSA

64,00 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Asthma Chronic Obstructive Pulmonary Disease Epilepsy Migraine Generalized Anxiety Disorder Systemic Lupus Erythematosus Chronic Kidney Disease Stroke Obesity Lymphoma Type 2 Diabetes Hypertension Breast Cancer Chronic Pain Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC

InChI

InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3

Molecular Formula

C27H38N2O4

HBD / HBA

- / 6

Ligações Rotacionáveis

13

Átomos Pesados

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

This calcium channel blocker is used to treat high blood pressure, certain heart rhythm disorders (including atrial fibrillation and supraventricular tachycardia), and angina (chest pain), and is also used to prevent migraine headaches and cluster headaches. It works by slowing the movement of calcium into heart and blood vessel muscle cells, causing the heart to beat more slowly and blood vessels to relax. It interacts with many medications, and grapefruit juice can increase its blood levels significantly.

Yes, Verapamil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6966. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 2520. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estrutura

Dados Rápidos

Fórmula: C27H38N2O4
Sinônimos: 4

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.