Valsartan

CHEMBL1069 Phase 4 Onaylandı Small molecule

Half-Life

6 hours

Bioavailability

—

Protein Binding

—

Molecular Weight

435.5 g/mol

LogP

4.4

Phase

4

This angiotensin receptor blocker (ARB) is used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, allowing them to relax and lower blood pressure. Like all ARBs, it should not be taken during pregnancy.

Moleküler Ağırlık

435,5190 g/mol

LogP

4,40

TPSA

112,00 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Ovarian Cancer Thyroid Cancer Cardiovascular Disease Pain Management Rheumatoid Arthritis Osteoporosis Chronic Obstructive Pulmonary Disease Systemic Lupus Erythematosus Chronic Kidney Disease Stroke Hyperlipidemia Obesity Lymphoma Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain HIV/AIDS Heart Failure Atrial Fibrillation

İlaç Sınıfları

C — C - Cardiovascular System

Etki Mekanizması

Angiotensin II type 1 receptor blocker.

Pharmacokinetics (PK)

Half-Life 6 hours

Pharmacodynamics (PD)

Mekanizma

Angiotensin II type 1 receptor blocker.

2D Yapı

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SMILES

CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C

InChI

InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1

Molecular Formula

C24H29N5O3

HBD / HBA

2 / 6

Döndürülebilir Bağlar

10

Ağır Atomlar

32

AGTR1 (Angiotensin II Type 1 Receptor) Antagonist

Primary Target

ABCB1 (P-glycoprotein) Substrate

Minor Valsartan + Digoxin

Valsartan may slightly increase digoxin plasma levels by reducing its renal clearance; the interaction is generally modest.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

This angiotensin receptor blocker (ARB) is used to treat high blood pressure, heart failure, and to improve survival after a heart attack. It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, allowing them to relax and lower blood pressure. Like all ARBs, it should not be taken during pregnancy.

Angiotensin II type 1 receptor blocker.

Key pharmacokinetic parameters for Valsartan: Half-life: 6 hours.

Yes, Valsartan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

Related Drugs

Same Drug Class

Atorvastatin Small molecule Amlodipine Small molecule Lisinopril Small molecule Metoprolol Small molecule

Same Target

Amlodipine Small molecule Losartan Small molecule Spironolactone Small molecule

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1069. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 60846. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Hızlı Veriler

Class: C - Cardiovascular System
Formül: C24H29N5O3
Eş Anlamlılar: 9

Dış Bağlantılar

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.

Valsartan

Terapötik Alanlar

İlaç Sınıfları

Etki Mekanizması

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

Cite this structure

Embed this structure

No side effects recorded

Sıkça Sorulan Sorular

Related Drugs

Same Drug Class

Same Target

References & Data Sources

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