Acyclovir
An antiviral medication that stops the herpes simplex and varicella-zoster viruses from replicating by mimicking one of the building blocks the virus needs to copy its DNA. It is used to treat cold sores, genital herpes, chickenpox, and shingles, and can reduce the severity and duration of outbreaks when started early. Long-term daily use at a lower dose can suppress recurrent outbreaks in people with frequent episodes.
Khối lượng phân tử
225,2050 g/mol
LogP
-1,90
TPSA
115,00 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Phân loại thuốc
Cơ chế tác dụng
Guanosine analogue inhibiting viral DNA polymerase.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Guanosine analogue inhibiting viral DNA polymerase.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Nc1nc2c(ncn2COCCO)c(=O)[nH]1
InChI
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
Molecular Formula
C8H11N5O3
HBD / HBA
3 / 5
Liên kết có thể quay
4
Nguyên tử nặng
16
Acyclovir has been associated with reduced phenytoin plasma concentrations in some patients, potentially compromising seizure control during antiviral therapy.
Concurrent use of acyclovir and cyclosporine can increase nephrotoxicity risk, as both agents are renally cleared and individually nephrotoxic.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
An antiviral medication that stops the herpes simplex and varicella-zoster viruses from replicating by mimicking one of the building blocks the virus needs to copy its DNA. It is used to treat cold sores, genital herpes, chickenpox, and shingles, and can reduce the severity and duration of outbreaks when started early. Long-term daily use at a lower dose can suppress recurrent outbreaks in people with frequent episodes.
Guanosine analogue inhibiting viral DNA polymerase.
Key pharmacokinetic parameters for Acyclovir: Half-life: 2.5-3.3 hours.
Yes, Acyclovir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL184. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135398513. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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