Avacopan
A selective complement C5a receptor antagonist taken by mouth that dampens the inflammatory response driven by the complement system in certain autoimmune vasculitides such as ANCA-associated vasculitis. It allows dose reduction of steroids while maintaining disease control.
Khối lượng phân tử
581,6000 g/mol
LogP
7,20
TPSA
61,40 Ų
Lipinski RO5
Không đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Cc1ccc(NC(=O)[C@H]2CCCN(C(=O)c3c(C)cccc3F)[C@H]2c2ccc(NC3CCCC3)cc2)cc1C(F)(F)F
InChI
InChI=1S/C33H35F4N3O2/c1-20-12-15-25(19-27(20)33(35,36)37)39-31(41)26-10-6-18-40(32(42)29-21(2)7-5-11-28(29)34)30(26)22-13-16-24(17-14-22)38-23-8-3-4-9-23/h5,7,11-17,19,23,26,30,38H,3-4,6,8-10,18H2,1-2H3,(H,39,41)/t26-,30-/m0/s1
Molecular Formula
C33H35F4N3O2
HBD / HBA
2 / 7
Liên kết có thể quay
6
Nguyên tử nặng
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A selective complement C5a receptor antagonist taken by mouth that dampens the inflammatory response driven by the complement system in certain autoimmune vasculitides such as ANCA-associated vasculitis. It allows dose reduction of steroids while maintaining disease control.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Avacopan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989871. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 49841217. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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