Clotrimazole
A broad-spectrum azole antifungal that disrupts fungal cell membranes by inhibiting ergosterol synthesis, used to treat athlete's foot, vaginal yeast infections, and oral thrush. It is available as creams, lozenges, and vaginal suppositories.
Khối lượng phân tử
344,8000 g/mol
LogP
5,00
TPSA
17,80 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
InChI
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
Molecular Formula
C22H17ClN2
HBD / HBA
- / 1
Liên kết có thể quay
4
Nguyên tử nặng
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A broad-spectrum azole antifungal that disrupts fungal cell membranes by inhibiting ergosterol synthesis, used to treat athlete's foot, vaginal yeast infections, and oral thrush. It is available as creams, lozenges, and vaginal suppositories.
Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.
Yes, Clotrimazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL104. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2812. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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