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Fezolinetant

CHEMBL3608680 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
358.4 g/mol
LogP
1.6
Phase
4

A non-hormonal medication that works by blocking neurokinin 3 receptors in the brain to reduce the frequency and severity of hot flashes in postmenopausal women. It provides relief without the use of estrogen, making it an option for those who cannot or prefer not to use hormone therapy.

Khối lượng phân tử

358,4000 g/mol

LogP

1,60

TPSA

105,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Cardiovascular Disease Breast Cancer Prostate Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H15FN6OS

                    

                    
                    

                        
HBD / HBA

                        
- / 7

                    

                    
                    

                        
Liên kết có thể quay

                        
2

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A non-hormonal medication that works by blocking neurokinin 3 receptors in the brain to reduce the frequency and severity of hot flashes in postmenopausal women. It provides relief without the use of estrogen, making it an option for those who cannot or prefer not to use hormone therapy.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Fezolinetant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3608680.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 117604931.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.