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Hydralazine

CHEMBL276832 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
160.2 g/mol
LogP
0.7
Phase
4

A direct-acting vasodilator that relaxes arterial smooth muscle to lower blood pressure, used to treat moderate to severe hypertension, heart failure, and hypertensive emergencies during pregnancy. It is often combined with other antihypertensives as it triggers reflex tachycardia and sodium retention when used alone. Research has explored its potential role in epigenetic regulation relevant to certain cancers.

Khối lượng phân tử

160,1800 g/mol

LogP

0,70

TPSA

63,80 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Cardiovascular Disease Non-Small Cell Lung Cancer Epilepsy Stroke Type 2 Diabetes Hypertension Breast Cancer Heart Failure Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
NNc1nncc2ccccc12

                

                

                
                

                    
InChI

                    
InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H8N4

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
1

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
12

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A direct-acting vasodilator that relaxes arterial smooth muscle to lower blood pressure, used to treat moderate to severe hypertension, heart failure, and hypertensive emergencies during pregnancy. It is often combined with other antihypertensives as it triggers reflex tachycardia and sodium retention when used alone. Research has explored its potential role in epigenetic regulation relevant to certain cancers.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Hydralazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL276832.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3637.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.