💊 Thuốc A-Z 🧬 Đích tác dụng 🛠 Công cụ 📚 Hướng dẫn
Tất cả thuốc Phân loại thuốc Lĩnh vực điều trị Tác dụng phụ
Hướng dẫn Từ điển thuật ngữ Dòng thời gian
So sánh Hành trình của thuốc Các họ thuốc
🇺🇸 English 🇰🇷 한국어 🇯🇵 日本語 🇨🇳 中文简体 🇪🇸 Español 🇧🇷 Português 🇮🇳 हिन्दी 🇸🇦 العربية 🇫🇷 Français 🇷🇺 Русский 🇩🇪 Deutsch 🇹🇷 Türkçe 🇻🇳 Tiếng Việt 🇮🇩 Bahasa Indonesia 🇹🇭 ไทย

Suxamethonium

CHEMBL703 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
290.4 g/mol
LogP
0.6
Phase
4

Suxamethonium (succinylcholine) is a depolarizing neuromuscular blocking agent that mimics acetylcholine at the neuromuscular junction nicotinic receptors, causing initial fasciculations followed by sustained depolarization and flaccid skeletal muscle paralysis used for rapid sequence induction and tracheal intubation. Its rapid onset of action (30-60 seconds) and short duration (10-15 minutes due to plasma cholinesterase hydrolysis) make it uniquely suited for emergency airway management. It carries risks of hyperkalemic cardiac arrest in patients with denervation injuries, burns, or prolonged immobility.

Khối lượng phân tử

290,4000 g/mol

LogP

0,60

TPSA

52,60 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Glaucoma Pain Management Rheumatoid Arthritis Schizophrenia Bipolar Disorder Infectious Disease Stroke Obesity Major Depressive Disorder Breast Cancer Chronic Pain Colorectal Cancer

Cơ chế tác dụng

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H30N2O4+2

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
11

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Suxamethonium (succinylcholine) is a depolarizing neuromuscular blocking agent that mimics acetylcholine at the neuromuscular junction nicotinic receptors, causing initial fasciculations followed by sustained depolarization and flaccid skeletal muscle paralysis used for rapid sequence induction and tracheal intubation. Its rapid onset of action (30-60 seconds) and short duration (10-15 minutes due to plasma cholinesterase hydrolysis) make it uniquely suited for emergency airway management. It carries risks of hyperkalemic cardiac arrest in patients with denervation injuries, burns, or prolonged immobility.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Suxamethonium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL703.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5314.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.