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Taurursodiol

CHEMBL272427 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
499.7 g/mol
LogP
3.6
Phase
4

Taurursodiol (sodium phenylbutyrate/ursodoxicoltaurine, also known as AMX0035) is a fixed-dose combination product that modulates endoplasmic reticulum stress and mitochondrial dysfunction, reducing neuronal and motor neuron apoptosis. It is approved for the treatment of amyotrophic lateral sclerosis (ALS) and is under investigation for neurodegenerative diseases. By targeting two complementary pathways of cell death, it offers a novel approach to neuroprotection.

Khối lượng phân tử

499,7000 g/mol

LogP

3,60

TPSA

132,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Asthma Multiple Sclerosis Obesity Type 2 Diabetes Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

                

                

                
                

                    
InChI

                    
InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H45NO6S

                    

                    
                    

                        
HBD / HBA

                        
4 / 6

                    

                    
                    

                        
Liên kết có thể quay

                        
7

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
34

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Taurursodiol (sodium phenylbutyrate/ursodoxicoltaurine, also known as AMX0035) is a fixed-dose combination product that modulates endoplasmic reticulum stress and mitochondrial dysfunction, reducing neuronal and motor neuron apoptosis. It is approved for the treatment of amyotrophic lateral sclerosis (ALS) and is under investigation for neurodegenerative diseases. By targeting two complementary pathways of cell death, it offers a novel approach to neuroprotection.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Taurursodiol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL272427.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9848818.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.