Tenofovir Disoproxil Phosphate
Tenofovir disoproxil phosphate is a phosphate salt formulation of tenofovir disoproxil, an NRTI prodrug used for HIV/AIDS treatment and prevention. See tenofovir-disoproxil for complete pharmacological details. This formulation has been investigated as an alternative to the fumarate salt.
Khối lượng phân tử
617,4000 g/mol
TPSA
263,00 Ų
Lĩnh vực điều trị
Cơ chế tác dụng
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C.O=P(O)(O)O
InChI
InChI=1S/C19H30N5O10P.H3O4P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;1-5(2,3)4/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);(H3,1,2,3,4)/t14-;/m1./s1
Molecular Formula
C19H33N5O14P2
HBD / HBA
4 / 18
Liên kết có thể quay
17
Nguyên tử nặng
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Tenofovir disoproxil phosphate is a phosphate salt formulation of tenofovir disoproxil, an NRTI prodrug used for HIV/AIDS treatment and prevention. See tenofovir-disoproxil for complete pharmacological details. This formulation has been investigated as an alternative to the fumarate salt.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Tenofovir Disoproxil Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6068341. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71714119. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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