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Zidovudine

CHEMBL129 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
267.2 g/mol
LogP
—
Phase
4

This antiretroviral medication (also known as AZT) was the first approved treatment for HIV infection and works by blocking reverse transcriptase, an enzyme the virus needs to copy its genetic material. It is now used as part of combination antiretroviral therapy and is also given to HIV-positive pregnant women and their newborns to reduce the risk of transmitting HIV from mother to child. Bone marrow suppression causing anemia is the main side effect requiring monitoring.

Khối lượng phân tử

267,2400 g/mol

LogP

0,00

TPSA

93,20 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Alzheimer's Disease Generalized Anxiety Disorder Psoriasis Chronic Kidney Disease Lymphoma Atopic Dermatitis Gout Malaria HIV/AIDS Hepatitis C Tuberculosis Cardiovascular Disease Colorectal Cancer Leukemia

Cơ chế tác dụng

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H13N5O4

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
Liên kết có thể quay

                        
3

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This antiretroviral medication (also known as AZT) was the first approved treatment for HIV infection and works by blocking reverse transcriptase, an enzyme the virus needs to copy its genetic material. It is now used as part of combination antiretroviral therapy and is also given to HIV-positive pregnant women and their newborns to reduce the risk of transmitting HIV from mother to child. Bone marrow suppression causing anemia is the main side effect requiring monitoring.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zidovudine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL129.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 35370.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.