Major
Probable
Mô tả
Diazepam and quetiapine together significantly increase CNS depression and carry risk of severe sedation and cardiorespiratory compromise.
Cơ chế
Additive CNS depression through complementary receptor mechanisms (GABA-A vs. H1/alpha-1/D2 blockade); quetiapine also prolongs QT, adding cardiac risk.
Ý nghĩa lâm sàng
Excess sedation and cardiovascular events are documented with the combination; particularly risky in elderly or medically ill patients.
Xử trí
Use at minimum doses only when clearly indicated; monitor sedation level, ECG, and vital signs.