Seratrodast
Seratrodast is a thromboxane A2 receptor antagonist used for the treatment of asthma in Japan and some Asian countries, where it reduces bronchoconstriction and airway inflammation mediated by thromboxane A2. By blocking thromboxane A2 prostanoid (TP) receptors on airway smooth muscle and inflammatory cells, it inhibits bronchoconstriction, platelet aggregation, and inflammatory cell recruitment. It provides anti-asthmatic effects without the direct bronchodilatory action of beta-agonists.
分子量
354.4000 g/mol
LogP
4.40
TPSA
71.40 Ų
Lipinski 五规则
符合
作用机制
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
二维结构
Cite this structure
Embed this structure
SMILES
CC1=C(C)C(=O)C(C(CCCCCC(=O)O)c2ccccc2)=C(C)C1=O
InChI
InChI=1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)
Molecular Formula
C22H26O4
HBD / HBA
1 / 4
可旋转键数
8
重原子数
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Seratrodast is a thromboxane A2 receptor antagonist used for the treatment of asthma in Japan and some Asian countries, where it reduces bronchoconstriction and airway inflammation mediated by thromboxane A2. By blocking thromboxane A2 prostanoid (TP) receptors on airway smooth muscle and inflammatory cells, it inhibits bronchoconstriction, platelet aggregation, and inflammatory cell recruitment. It provides anti-asthmatic effects without the direct bronchodilatory action of beta-agonists.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Seratrodast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL70972. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2449. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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