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Zafirlukast

CHEMBL603 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
575.7 g/mol
LogP
5.5
Phase
4

This leukotriene receptor antagonist is taken as a daily oral tablet to prevent asthma symptoms and reduce the need for rescue inhalers. It works by blocking leukotrienes, inflammatory chemicals that cause airway narrowing, mucus production, and swelling in asthma. It is not for immediate relief of an asthma attack and should be continued even when symptoms are absent.

分子量

575.7000 g/mol

LogP

5.50

TPSA

124.00 Ų

Lipinski 五规则

不符合

治疗领域

Ovarian Cancer Asthma Breast Cancer

作用机制

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12

                

                

                
                

                    
InChI

                    
InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)

                

                

                

                    
                    

                        
Molecular Formula

                        
C31H33N3O6S

                    

                    
                    

                        
HBD / HBA

                        
2 / 6

                    

                    
                    

                        
可旋转键数

                        
9

                    

                    
                    
                    

                        
重原子数

                        
41

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This leukotriene receptor antagonist is taken as a daily oral tablet to prevent asthma symptoms and reduce the need for rescue inhalers. It works by blocking leukotrienes, inflammatory chemicals that cause airway narrowing, mucus production, and swelling in asthma. It is not for immediate relief of an asthma attack and should be continued even when symptoms are absent.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zafirlukast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL603.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5717.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.