Narrow Therapeutic Index (NTI)
NTIA drug for which small changes in dose or blood concentration can lead to serious therapeutic failures or adverse effects. Requires careful dose titration, therapeutic drug monitoring, and bioequivalence scrutiny.
示例
- Warfarin
- Lithium
- Digoxin
- Phenytoin
- Cyclosporine
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A drug for which small changes in dose or blood concentration can lead to serious therapeutic failures or adverse effects. Requires careful dose titration, therapeutic drug monitoring, and bioequivalence scrutiny.