Trimethaphan

CHEMBL1201329 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

365.5 g/mol

LogP

3.6

Phase

4

Trimethaphan is a ganglionic blocking agent that competitively antagonizes nicotinic acetylcholine receptors at both sympathetic and parasympathetic ganglia, producing rapid and controllable hypotension. It was used for controlled hypotension during surgery and for the management of hypertensive emergencies, particularly aortic dissection. Its short duration of action allowed for precise blood pressure control via intravenous infusion.

Masse moléculaire

365,5000 g/mol

LogP

3,60

TPSA

24,60 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Obesity Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

SVG PNG

Cite this structure

Embed this structure

SMILES

O=C1N(Cc2ccccc2)C2C[S+]3CCCC3C2N1Cc1ccccc1

InChI

InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

Molecular Formula

C22H25N2OS+

HBD / HBA

- / 1

Liaisons Rotatives

4

Atomes Lourds

26

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Trimethaphan is a ganglionic blocking agent that competitively antagonizes nicotinic acetylcholine receptors at both sympathetic and parasympathetic ganglia, producing rapid and controllable hypotension. It was used for controlled hypotension during surgery and for the management of hypertensive emergencies, particularly aortic dissection. Its short duration of action allowed for precise blood pressure control via intravenous infusion.

Yes, Trimethaphan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201329. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 23576. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

Vous cherchez des informations accessibles aux patients ?

Trimethaphan sur PillFYI

Structure

Données Clés

Formule: C22H25N2OS+

Liens externes

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.