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Loading Dose

Pharmacokinetics

An initial higher dose given to rapidly achieve therapeutic plasma concentrations before steady state. Calculated as Vd * target concentration / bioavailability.

Exemples

  • Digoxin 0.5-1mg loading
  • Amiodarone IV loading
  • Phenytoin 15-20mg/kg loading

Le saviez-vous ?

An initial higher dose given to rapidly achieve therapeutic plasma concentrations before steady state. Calculated as Vd * target concentration / bioavailability.