Minor
Suspected
설명
Ranitidine may reduce the absorption rate of cephalexin by raising gastric pH, but overall bioavailability is not substantially altered, making this interaction clinically insignificant.
기전
Acid suppression by ranitidine can alter the dissolution rate of cephalexin capsules, potentially delaying Tmax; total absorption (AUC) is largely unaffected.
임상적 중요성
No clinically meaningful reduction in cephalexin efficacy has been documented; the interaction is considered theoretical.
관리 방법
No dose adjustment or timing modification is required.