Minor
Suspected
Mô tả
Ranitidine may reduce the absorption rate of cephalexin by raising gastric pH, but overall bioavailability is not substantially altered, making this interaction clinically insignificant.
Cơ chế
Acid suppression by ranitidine can alter the dissolution rate of cephalexin capsules, potentially delaying Tmax; total absorption (AUC) is largely unaffected.
Ý nghĩa lâm sàng
No clinically meaningful reduction in cephalexin efficacy has been documented; the interaction is considered theoretical.
Xử trí
No dose adjustment or timing modification is required.