Minor
Suspected
Descrição
Ranitidine may reduce the absorption rate of cephalexin by raising gastric pH, but overall bioavailability is not substantially altered, making this interaction clinically insignificant.
Mecanismo
Acid suppression by ranitidine can alter the dissolution rate of cephalexin capsules, potentially delaying Tmax; total absorption (AUC) is largely unaffected.
Significância Clínica
No clinically meaningful reduction in cephalexin efficacy has been documented; the interaction is considered theoretical.
Conduta
No dose adjustment or timing modification is required.