PDCD1 (Programmed Cell Death Protein 1)
PDCD1
Immune checkpoint receptor on T cells that suppresses anti-tumor immunity.
기능
PD-1 inhibitors (pembrolizumab, nivolumab) reactivate exhausted T cells against tumors.
이 표적에 작용하는 약물
| 약물 | 작용 | 주요 |
|---|---|---|
| Pembrolizumab | Antagonist | 예 |
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SIGMAR1 (Sigma-1 Receptor)
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CTLA4 (Cytotoxic T-Lymphocyte Antigen 4)
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ADRB1 (Beta-1 Adrenergic Receptor)
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ADRB2 (Beta-2 Adrenergic Receptor)
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DRD2 (Dopamine D2 Receptor)
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HRH2 (Histamine H2 Receptor)
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