Fedratinib

CHEMBL1287853 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

524.7 g/mol

LogP

4.8

Phase

4

This oral medication blocks JAK2, an enzyme that is overactivated in certain blood cancers, slowing the abnormal growth of blood cells. It is used to treat myelofibrosis and polycythemia vera.

Peso Molecular

524,7000 g/mol

LogP

4,80

TPSA

117,00 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1

InChI

InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

Molecular Formula

C27H36N6O3S

HBD / HBA

3 / 9

Ligações Rotacionáveis

11

Átomos Pesados

37

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

This oral medication blocks JAK2, an enzyme that is overactivated in certain blood cancers, slowing the abnormal growth of blood cells. It is used to treat myelofibrosis and polycythemia vera.

Yes, Fedratinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1287853. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 16722836. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

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Fedratinib no PillFYI

Estrutura

Dados Rápidos

Fórmula: C27H36N6O3S
Sinônimos: 1

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.