Lumefantrine

CHEMBL38827 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

528.9 g/mol

LogP

8.7

Phase

4

This antimalarial drug is used exclusively in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum, including strains resistant to older drugs like chloroquine. It works by accumulating in infected red blood cells and interfering with the parasite's ability to detoxify heme, a byproduct of its digestion of hemoglobin.

Peso Molecular

528,9000 g/mol

LogP

8,70

TPSA

23,50 Å²

Regra dos 5 de Lipinski

Reprovado

Áreas Terapêuticas

Malaria HIV/AIDS Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1

InChI

InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-

Molecular Formula

C30H32Cl3NO

HBD / HBA

1 / 2

Ligações Rotacionáveis

10

Átomos Pesados

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

This antimalarial drug is used exclusively in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum, including strains resistant to older drugs like chloroquine. It works by accumulating in infected red blood cells and interfering with the parasite's ability to detoxify heme, a byproduct of its digestion of hemoglobin.

Yes, Lumefantrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL38827. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6437380. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Estrutura

Dados Rápidos

Fórmula: C30H32Cl3NO
Sinônimos: 1

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.