Pralidoxime

CHEMBL1420 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

137.2 g/mol

LogP

1.0

Phase

4

Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.

Peso Molecular

137,1600 g/mol

LogP

1,00

TPSA

36,50 Å²

Regra dos 5 de Lipinski

Aprovado

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

C[n+]1ccccc1C=NO

InChI

InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1

Molecular Formula

C7H9N2O+

HBD / HBA

1 / 2

Ligações Rotacionáveis

1

Átomos Pesados

10

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.

Yes, Pralidoxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1420. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135398747. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

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Pralidoxime no PillFYI

Estrutura

Dados Rápidos

Fórmula: C7H9N2O+
Sinônimos: 3

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.