Pralidoxime
Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.
Khối lượng phân tử
137,1600 g/mol
LogP
1,00
TPSA
36,50 Ų
Lipinski RO5
Đạt
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
C[n+]1ccccc1C=NO
InChI
InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1
Molecular Formula
C7H9N2O+
HBD / HBA
1 / 2
Liên kết có thể quay
1
Nguyên tử nặng
10
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.
Yes, Pralidoxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1420. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135398747. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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