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Irbesartan

CHEMBL1513 Phase 4 已批准 Small molecule
Half-Life
11-15 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
428.5 g/mol
LogP
4.1
Phase
4

This angiotensin II receptor blocker (ARB) is used to treat high blood pressure, heart failure, and kidney disease in patients with type 2 diabetes. It works by blocking the AT1 receptor for angiotensin II, causing blood vessels to relax and reducing aldosterone secretion. It is often used in patients who cannot tolerate ACE inhibitors due to cough.

分子量

428.5320 g/mol

LogP

4.10

TPSA

87.10 Ų

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Cardiovascular Disease Chronic Kidney Disease Stroke Hyperlipidemia Obesity Type 2 Diabetes Hypertension Hepatitis C Heart Failure Atrial Fibrillation

药物分类

C — C - Cardiovascular System

作用机制

Selective non-competitive angiotensin II type 1 receptor antagonist.

Pharmacokinetics (PK)

Half-Life 11-15 hours

Pharmacodynamics (PD)

机制

Selective non-competitive angiotensin II type 1 receptor antagonist.

二维结构

SVG PNG

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SMILES

                    
CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H28N6O

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
可旋转键数

                        
7

                    

                    
                    
                    

                        
重原子数

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This angiotensin II receptor blocker (ARB) is used to treat high blood pressure, heart failure, and kidney disease in patients with type 2 diabetes. It works by blocking the AT1 receptor for angiotensin II, causing blood vessels to relax and reducing aldosterone secretion. It is often used in patients who cannot tolerate ACE inhibitors due to cough.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Selective non-competitive angiotensin II type 1 receptor antagonist.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Irbesartan: Half-life: 11-15 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Irbesartan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
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                            Small molecule
                        
                        
                        
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                            Small molecule
                        
                        
                        
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                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1513.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3749.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.