Receptor Desensitization

Pharmacodynamics

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.

Beispiele

Beta-2 agonist tachyphylaxis
Opioid tolerance
Nicotinic receptor desensitization

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Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.