Receptor Desensitization

Pharmacodynamics

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.

예시

Beta-2 agonist tachyphylaxis
Opioid tolerance
Nicotinic receptor desensitization

알고 계셨나요?

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.