Receptor Desensitization

Pharmacodynamics

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.

Exemples

Beta-2 agonist tachyphylaxis
Opioid tolerance
Nicotinic receptor desensitization

Le saviez-vous ?

Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.