SLC6A4 (Serotonin Transporter)
SLC6A4
Sodium-dependent serotonin transporter responsible for reuptake of 5-HT from the synaptic cleft.
功能
Primary target for SSRIs and SNRIs. Inhibition increases synaptic serotonin.
作用于该靶点的药物
| 药物 | 作用 | 主要 |
|---|---|---|
| Sertraline | Inhibitor | 是 |
| Escitalopram | Inhibitor | 是 |
| Fluoxetine | Inhibitor | 是 |
| Duloxetine | Inhibitor | 是 |
| Venlafaxine | Inhibitor | 是 |
| Tramadol | Inhibitor | 是 |
| Ondansetron | Other | 是 |
| Quetiapine | Inhibitor | — |
| Bupropion | Inhibitor | — |
| Trazodone | Inhibitor | — |
| Sumatriptan | Other | — |
| Aripiprazole | Partial Agonist | — |