DRD2 (Dopamine D2 Receptor)
DRD2
G-protein coupled receptor (Gi/o) mediating dopaminergic neurotransmission.
İşlev
Key target for antipsychotic drugs (antagonists) and anti-parkinsonian agents (agonists). D2 blockade in the mesolimbic pathway reduces positive psychotic symptoms.
Bu Hedefe Etki Eden İlaçlar
| İlaç | Etki | Birincil |
|---|---|---|
| Quetiapine | Antagonist | Evet |
| Aripiprazole | Partial Agonist | Evet |
Related Targets
ADRB1 (Beta-1 Adrenergic Receptor)
ADRB1
ADRB2 (Beta-2 Adrenergic Receptor)
ADRB2
AGTR1 (Angiotensin II Type 1 Receptor)
AGTR1
OPRM1 (Mu-Opioid Receptor)
OPRM1
SIGMAR1 (Sigma-1 Receptor)
SIGMAR1
PDCD1 (Programmed Cell Death Protein 1)
PDCD1
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4)
CTLA4
HRH2 (Histamine H2 Receptor)
HRH2