SCN9A (Sodium Channel Nav1.7)
SCN9A
Voltage-gated sodium channel preferentially expressed in nociceptive neurons.
기능
Gain-of-function mutations cause inherited pain disorders. Blocking reduces pain signaling.
이 표적에 작용하는 약물
| 약물 | 작용 | 주요 |
|---|---|---|
| Valproic Acid | Blocker | 예 |
| Topiramate | Blocker | 예 |
| Phenytoin | Blocker | 예 |
| Gabapentin | Blocker | 예 |
| Pregabalin | Blocker | 예 |
| Lamotrigine | Blocker | 예 |
| Carbamazepine | Blocker | 예 |
| Furosemide | Inhibitor | 예 |
| Hydrochlorothiazide | Inhibitor | 예 |